Spravato (esketamine) is a prescription medication used to treat treatment-resistant depression (TRD) in adults. It is a nasal spray formulation of esketamine, which is a derivative of ketamine, an anesthetic that has also been used for pain relief and depression.
Spravato is typically used in conjunction with an oral antidepressant and is administered under the supervision of a healthcare provider in a certified medical office or clinic due to its potential for serious side effects, including sedation and dissociation. The medication has shown rapid antidepressant effects, often within hours to days, making it a valuable option for individuals who have not responded to other treatments.
